Research & reviews
This study shows that HIV-infected individuals have a lower risk of developing AIDS or other serious illnesses if they start taking ART sooner:
The INSIGHT START study group Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection
. N Engl J Med 2015; 373:795-807August 27, 2015DOI: 10.1056/NEJMoa150681
These papers show the impact of HIV treatment (antiretroviral therapy, ART) on mortality and confirm that it is highly cost effective:
Walensky RP, Paltiel AD, Losina E, et al. The survival benefits of AIDS treatment in the United States
. J. Infect. Dis. 2006;194(1):11–19
Sendi P, Butcher H, Harr T et al. Cost effectiveness of highly active antiretroviral therapy in HIV infected patients: Swiss HIV Cohort study
. AIDS 1999; 13: 1115–1122.
Miners AH, Sabin CA, Trueman P et al. Assessing cost effectiveness of highly active antiretroviral therapy for adults with HIV in England
. HIV Med 2001; 2: 52–58.
Freedberg KA, Losina E, Weinstein MC et al. The cost effectiveness of combination antiretroviral therapy in HIV disease
. N Engl J Med 2001; 344: 824–831
These papers show that late diagnosis of HIV is associated with higher costs:
Beck EJ, Mandalia S, Sangha R et al. The cost effectiveness of early access to HIV services and starting cART in the UK 1996–2008
. PLoS ONE 2011; 6: e27830.
Beck EJ, Mandalia S, Lo G et al. Cost-effectiveness of early treatment with first-line NNRTI-based HAART regimens in the UK
, 1996–2006. PLoS ONE 2011; 6: e20200.
This study showed that people whose HIV is treated are much much less likely to transmit HIV to their partner:
Cohen MS et al Prevention of HIV-1 Infection with early Antiretroviral Therapy
. New England Journal of Medicine 365; 493-505. 2011
These studies provide evidence that HIV is being missed in general practice and other healthcare settings and that a routine offer of HIV testing is acceptable to patients:
Burns FM, Johnson AM, Nazroo J, Ainsworth J, Anderson J, Fakoya A, et al. Missed opportunities for earlier HIV diagnosis within primary and secondary healthcare settings in the UK
. AIDS. 2008 Jan 2;22(1):115-22.
Sudarshi D, Pao D, Murphy G, Parry J, Dean G, Fisher M. Missed opportunities for diagnosing primary HIV infection
. Sex Transm Infect. 2008 Feb; 84(1):14-6.
Bates SM. HIV testing in abortion clinics
, J Fam Plann Reprod Health Care 2011;37:198–200. doi:10.1136/jfprhc-2011-100136
Adrian Palfreeman, Farai Nyatsanza, Helen Farn, Graham McKinnon, Paul Schober, Paul McNally. HIV testing for acute medical admissions: evaluation of a pilot study in Leicester, England.
Sex Transm Infect 2013;89:308-310 doi:10.1136/sextrans-2011-050401